منابع مشابه
Fluconazole resistance in Candida glabrata.
We report a case of infection with Candida glabrata in which the organism became resistant to fluconazole and in which pre- and posttreatment isolates were available for comparison. The organism was cross-resistant to ketoconazole and itraconazole, in common with other azole-resistant yeasts. Fluconazole was a potent inhibitor of cytochrome P-450-dependent 14 alpha-sterol demethylase (P-450DM) ...
متن کاملInteractions between copy number and expression level of genes involved in fluconazole resistance in Candida glabrata
OBJECTIVES This study aimed to elucidate the relative involvement of drug resistance gene copy number and overexpression in fluconazole resistance in clinical C. glabrata isolates using a population-based approach. METHODS Fluconazole resistance levels were quantified using the minimal inhibitory concentration (MIC) via Etest method. Both gene expression levels and gene copy number of CgCDR1,...
متن کاملFluconazole resistance due to energy-dependent drug efflux in Candida glabrata.
We report on the mechanism of fluconazole resistance in Candida glabrata from a case of infection in which pre- and posttreatment isolates were available for comparison. The resistant, posttreatment isolate was cross-resistant to ketoconazole and itraconazole, in common with other azole-resistant yeasts. Resistance was due to reduced levels of accumulation of [3H]fluconazole rather than to chan...
متن کاملJjj1 Is a Negative Regulator of Pdr1-Mediated Fluconazole Resistance in Candida glabrata
The high prevalence of fluconazole resistance among clinical isolates of Candida glabrata has greatly hampered the utility of fluconazole for the treatment of invasive candidiasis. Fluconazole resistance in this yeast is almost exclusively due to activating mutations in the transcription factor Pdr1, which result in upregulation of the ABC transporter genes CDR1, PDH1, and SNQ2 and therefore in...
متن کاملRisk factors for fluconazole-resistant Candida glabrata bloodstream infections.
BACKGROUND Bloodstream infections (BSIs) caused by Candida glabrata have increased substantially. Candida glabrata is often associated with resistance to fluconazole therapy. However, to our knowledge, risk factors for fluconazole-resistant C glabrata BSIs have not been studied. METHODS A case-case-control study was conducted at 3 hospitals from January 1, 2003, to May 31, 2007. The 2 case gr...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 1993
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.37.9.1962